Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins
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چکیده
منابع مشابه
Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins.
The anaerobic bacterium Clostridium difficile is the etiologic agent of pseudomembranous colitis. C. difficile toxins TcdA and TcdB are UDP-glucosyltransferases that monoglucosylate and thereby inactivate the Rho family of GTPases (W. P. Ciesla, Jr., and D. A. Bobak, J. Biol. Chem. 273:16021-16026, 1998). We utilized purified reference toxins of C. difficile, TcdA-10463 (TcdA) and TcdB-10463 (T...
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Intestinal epithelial tight junctions (TJs) are a specialized structure that determines the cell polarity and prevents the diffusion of toxins, allergens, and pathogens from the lumen into the tissue. TJs are highly dynamic and its constituent protein complexes undergo continuously remodeling and turnover under tight regulation by numerous extracellular and intracellular factors. RNA-binding pr...
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Lactobacillus plantarum, a commensal bacterium of humans, has been proposed to enhance the intestinal barrier, which is compromised in a number of intestinal disorders. To study the effect of L. plantarum strain WCFS1 on human barrier function, healthy subjects were administered L. plantarum or placebo in the duodenum for 6 h by means of a feeding catheter. The scaffold protein zonula occludens...
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Jurgen Karczewski,* Freddy J. Troost,* Irene Konings, Jan Dekker, Michiel Kleerebezem, Robert-Jan M. Brummer, and Jerry M. Wells TI Food & Nutrition, Nieuwe Kanaal, Wageningen; Host-Microbe Interactomics Group, Animal Sciences, University of Wageningen; Department of Internal Medicine, Division of Gastroenterology & Hepatology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Ma...
متن کاملTransmembrane proteins in the tight junction barrier.
Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for regulating the paracellular permeability for water, solutes, and immune cells. Several of these proteins localize specifically within the continuous cell-to-cell contacts of the tight junction. One of these, occludin, is a cell adhesion m...
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ژورنال
عنوان ژورنال: The Journal of Biochemistry
سال: 2017
ISSN: 0021-924X,1756-2651
DOI: 10.1093/jb/mvx077